Six Nations (or Six Nations of the Grand River) is the largest First Nations reserve in Canada by populations and the second largest reserve by size. Located between Hamilton, Brantford and Simcoe, Ontario, Six Nations is the only reserve in North America where all six Iroquois nations live together. These nations include the Mohawk, Cayuga, Onondaga, Oneida, Seneca and Tuscarora.
Prior to the American Revolution, the Iroquois lived in the northeastern United States, primarily in what is referred to today as Central New York, west of the Hudson River and through to the Finger Lake (Great Lakes) Region. During this time the Iroquois were governed by the Haudenosaunee Confederacy.